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The Association between Proton Pump Inhibitors and C. Difficile

Posted by medliorator on May 11, 2010

investigators conducted a secondary analysis of prospectively collected data from 101,796 patients who were discharged from a tertiary care medical center during a 5-year period. Acid suppression treatment was the primary exposure of interest, classified by intensity (no acid suppression, histamine2-receptor antagonist [H2RA] treatment, daily PPI use, and PPI use more often than daily).

The risk for nosocomial C difficile infection increased with increasing level of acid suppression. This risk was 0.3% (95% confidence interval [CI], 0.21% – 0.31%) in patients not receiving acid suppressive treatment, 0.6% (95% CI, 0.49% – 0.79%) in those receiving H2RA treatment, 0.9% (95% CI, 0.80% – 0.98%) in those using PPIs daily, and 1.4% (95% CI, 1.15% – 1.71%) in patients using PPIs more often than daily …The odds ratio was 1 for no acid suppression (reference), 1.53 for H2RA treatment (95% CI, 1.12 – 2.10), 1.74 for daily PPI use (95% CI, 1.39 – 2.18), and 2.36 for more frequent PPI use (95% CI, 1.79 – 3.11).

Proton Pump Inhibitor Use Linked to Clostridium Difficile Infection [Medscape]

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