Medliorate

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Fertility Drugs and Ovarian Cancer – No Associations Found

Posted by medliorator on February 13, 2009

Participants 54 362 women with infertility problems referred to all Danish fertility clinics during 1963-98. 

Main outcome measure Effect of four groups of fertility drugs (gonadotrophins, clomifene citrate, human chorionic gonadotrophin, and gonadotrophin releasing hormone) on overall risk of ovarian cancer after adjustment for potential confounding factors.

Results Analyses within cohort showed no overall increased risk of ovarian cancer after any use of gonadotrophins (rate ratio 0.83, 95% confidence interval 0.50 to 1.37), clomifene (1.14, 0.79 to 1.64), human chorionic gonadotrophin (0.89, 0.62 to 1.29), or gonadotrophin releasing hormone (0.80, 0.42 to 1.51). Furthermore, no associations were found between all four groups of fertility drugs and number of cycles of use, length of follow-up, or parity.

Conclusion No convincing association was found between use of fertility drugs and risk of ovarian cancer.

Use of fertility drugs and risk of ovarian cancer: Danish population based cohort study [BMJ]

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